Day 3
11:25 Ying Swan Ho
Metabolomics-Based Approaches to Drive the Development of Optimal Biotherapeutics Production Processes and the Unravelling of Disease Mechanisms
11:55 Tomoya Kinumi
Reference material: Tool for traceable measurement and characterization of monoclonal antibody
12:10 Naoki Kawase
Multi Attribute Method for antibody therapeutics
12:25 Takeshi Ota
Utilizing of Antigens with Uniformed N-linked Glycans Facilitate Epitope Analysis of Glycoproteins via HDX-MS
Organized by Susumu Uchiyama (The University of Osaka, Japan) and Nana Kawasaki (Yokohama City University, Japan)
Nowadays, pharmaceuticals are not only traditional small-molecule drugs, but are also being developed in a variety of ‘modalities’, such as proteins, nucleic acids, protein complexes and nucleic acid-lipid complexes, which have complex structures and large molecular weights, and the manufacturing methods have also diversified to include chemical synthesis, biotechnology and combinations thereof. Mass spectrometry, on the other hand, is an indispensable analytical technique regardless of modality, from production to quality analysis of formulations and even post-administration pharmacokinetics. In two sessions of this annual meeting, several pharmaceutical modalities that have emerged in recent years will be introduced and discussed, with examples of research on each modality and the role played by mass spectrometry.
11:25 Yang Pan
Developments of laser desorption Post-photoionization Mass Spectrometry Imaging Techniques
11:40 Thomas Ka Yam Lam
Single Tissue Multimodal Imaging for Cellular-level Spatial Metabolomics and Transcriptomics Analysis
11:55 Hisako Akiyama
Fully automated surface lipidomics by LC/differential ion mobility spectrometry/MS reveals alteration of brain lipid metabolism in prodromal Parkinson’s disease model mice
12:10 Akiko Kubo
MS Imaging of Natural Moisturizing Factors in Mouse Skin
12:25 Craig Wheelock
Targeted spatial metabolomics and transcriptomics for mapping metabolism in the human lung
Organized by Shuichi Shimma (The University of Osaka, Japan)
This session explores cutting-edge developments in mass spectrometry imaging (MSI) techniques and instrumentation as a continuous session from 2A-O3. We will discuss new methodologies and instruments applicable to medicine, pharmaceuticals, and other fields. Presentations will address current technical challenges and their potential solutions. Participants will gain insights into the latest MSI trends and technologies. This session aims to facilitate discussions between developers, researchers, and potential users, promoting innovation and advancing the field.
11:25 Fan-Yan Wei
RNA epitranscriptome in clinical diagnosis and beyond
11:40 Cristian Arsene
Xlinking MS for structure analysis of tau/phosphorylated tau and other proteins
11:55 Shogo Urakami
Towards Rapid and Accurate Bacterial Serotyping Using MALDI Glycotyping
12:10 Yuta Matsuoka
Breath biomarkers for monitoring lipid peroxidation and ferroptosis in vivo
12:25 Mayo Wada
Molecular composition and imaging profiles of thrombi in acute coronary syndrome
Organized by Daisuke Saigusa (Teikyo University, Japan) and Masamitsu Maekawa (Tohoku University, Japan)
Mass spectrometry has been used in chemical diagnosis of diseases due to its usefulness in measuring various biomolecules. Furthermore, it has also been put to good use in the quantitative analysis of pharmaceuticals in recent years, and is contributing to more precise medical care. In addition, many new studies of pathological molecular mechanisms have been discovered through reverse translational research based on the results of clinical research. The aim of this session is to discuss the frontier of clinical mass spectrometry in chemical diagnosis and optimization of patient treatment, as well as in reverse translational research.
13:55 Susumu Uchiyama
Biophysical characterization of virus vectors for gene therapy by mass spectrometry
14:10 I-Lin Tsai
Comprehensive Glycomic Profiling of Immunoglobulin G, A, and M in Tuberculosis: Insights into Active and Latent Infection in the Elderly
14:25 Dukjin Kang
Quantitative proteomic analysis of SCN1A gene knockout in cerebral organoids during differentiation for underlying Dravet syndrome
14:40 Yuki Matsubara
Sequence Characterization for RNA Therapeutics: Leveraging Multiple Ribonucleases and DIA Mass Spectrometry
14:55 Ryoji Nakatsuka
Multimass Analysis of Adeno-Associated Virus Vectors by Orbitrap-Based Charge Detection Mass Spectrometry
Organized by Nana Kawasaki (Yokohama City University, Japan) and Susumu Uchiyama (The University of Osaka, Japan)
Continued from “Mass Spectrometry in Therapeutic Modality Research-1”.
13:55 Eisuke Hayakawa
Network-based Integration of Cross-Study Metabolomics Data
14:10 Han Bin Oh
Development of LC-MS/MS Software for Controlled Substance Identification
14:25 Mitsutoshi Setou
AI-Driven Analysis of Mass Spectrometry Imaging
14:40 Ayumi Kubo
Improving structure elucidation using machine learning for non-target analysis using Gas Chromatograph-Mass Spectrometer
14:55 Yushi Takahashi
Multiple Omics Data Repositories for Comprehensive Reanalysis of Mass Spectrometry Data
Organized by Fumio Matsuda (The University of Osaka, Japan)
Mass spectrometers generate large amounts of data. In this session, we would like to discuss building a network for sharing and utilizing data.
13:55 Yu Bai
Dynamic single-cell metabolomics platform and the application in cell-cell interaction
14:10 Hajime Mizuno
Localization Analysis of Metabolites in Living Cells by Live Single-cell Mass Spectrometry
14:25 Radoslaw Sobota
Application of ultrasensitive mass spectrometry-based single cell proteomics to address individual cell response
14:40 Huan-Chi Chiu
MiProChip: Microfluidic Device for Multiplexed Isotopic labeling-based Streamlined Single-cell Profiling
14:55 Yoshihiro Izumi
Multi-omics measurement platform driving next-generation biomanufacturing
Organized by Yasushi Ishihama (Kyoto University, Japan) and Takeshi Bamba (Kyushu University, Japan)
The aim of this session is to present and discuss the latest research on single-cell omics, which is developing rapidly, and multi-omics, which combines multiple omics analyses. Speakers from a wide range of countries will be selected to present not only on technology but also on applications, and future directions for this field will also be discussed together with the audience.
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Don’t forget:
June
22-25, 2025
Ishigaki, Japan
© 2025 AOMSC2025 committee. All Rights Reserved.